Solutions to challenging societal issues are ideally developed within an interdisciplinary context. The purpose of this research was to assess the effectiveness of computer-based learning (CBL) activities in promoting interdisciplinary thinking in students investigating the intersecting disciplines of weed management and public health. Students completed a CBL module (Health Solutions) to acquire foundational weed management concepts. Subsequently, students utilized a second module (Challenges-Choices-Consequences) that presented them with a series of weed management challenges. Challenges were associated with weed management choices that were in turn linked to potential consequences in production and public health. Concept maps and post activity surveys assessed changes in interdisciplinary thinking. Interdisciplinary concept map scores increased 45% after completing the CBL modules. 92% of students agreed with the statement “Completing the two health solution programs has helped me better understand the multiple factors involved in developing a weed management plan that includes public health considerations.” Survey responses and changes in concept map scores supported the premise that the CBL modules boosted interdisciplinary thinking. Results support the premise that CBL simulation activities foster critical interdisciplinary thinking skills needed to address complex issues rooted in agriculture and public health.